Is Johns Hopkins studying a similar treatment to the Russians?: TRBV9-Targeted Bispecific T Cell-Engaging Antibodies to Reset the Autoreactive T Cell Compartment in Spondyloarthritis

2024.11.29 22:50 rickjames730 Is Johns Hopkins studying a similar treatment to the Russians?: TRBV9-Targeted Bispecific T Cell-Engaging Antibodies to Reset the Autoreactive T Cell Compartment in Spondyloarthritis

Is Johns Hopkins studying a similar treatment to the Russians?: TRBV9-Targeted Bispecific T Cell-Engaging Antibodies to Reset the Autoreactive T Cell Compartment in Spondyloarthritis submitted by rickjames730 to ankylosingspondylitis [link] [comments]


2024.11.29 22:50 Scribblyr How Could Lioness Bring Aaliyah Back in a Plausible, Organic Way?

I doubt Aaliyah will be making any triumphant return to Lioness in the coming seasons, but I can imagine scenarios where it wouldn't seem like such a stretch.
Here's my best crack at it. Skip down to read the scenario without the screencraft and story analysis by going to the line “Imagine…”
I'd love to hear your ideas as well for how such a return might happen.
Consider...
To reintroduce a character like Aaliyah in an authentic fashion, you ask what valid ties her character has to the core story. The circumstances that brought Aaliyah into Lioness Season I depended entirely on a storyline specific to that season: the Lioness team targeting her father. That’s done and gone. Realistically, what’s left that might draw Aaliyah back into show’s narrative in an organic manner?
In Aaliyah's case, two links to the larger scope of the series leap out: her connection to Cruz and the network her father operated as a terrorist financier. Bringing Aaliyah back into the series by reuniting her with Cruz reeks of the most maudlin melodrama. Both characters have every reason to stay as far away from each other as possible: Aaliyah's (presumed) hatred toward Cruz for killing her father and Cruz's guilt for having killed him. Likewise, giving Aaliyah a role as a terrorist or power player would feel contrived. But the mere connections Aaliyah's father and the family have to terrorism? Those are a different matter.
The Amrohi family is obviously steeped in a world of terrorist activity. When you're a criminal, your friends are criminal associates. You don't fill a wedding of full hundreds of guests under terrorist kingpin levels of security without those guests knowing who they are dealing with and many of them sharing similar origins. Given these obvious connections, it's entirely plausible that - after the untimely death of Aaliyah's first fiancé's at the end of Cruz’s kitchen knife - Aaliyah's family chose to marry her off to someone who travels in similar circles. This might be especially true if the death of the family patriarch left her clan vulnerable to attack from competing radical elements and in need of new alliances - an entirely plausible hypothesis.
With that premise for connecting Aaliyah the general milieu of the series, we have to attack the question of bringing her back into the orbit of the CIA and the Lioness program, specifically. Here, we once again have two pretty clear links in the form of leverage the agency might use to compel her to help them target her new husband or someone else in that world. The agency has audio tape of Aaliyah having sex and pillow talk with another woman - enough to get her killed if the wrong people found out about it. And, of course, Langley has access to extraordinary personal insights about Aaliyah through Cruz – desires, fears, hopes, dreams, nightmares. In other words, Ayaliah is plausible target to be co-opted, precisely because she was previously a mark and that previous operation yielded damaging intel.
Cruz, of course, would want nothing to with any of this, and Aaliyah would want nothing to with her, but those complications create storytelling opportunities of their own.
Imagine...
Byron takes the fall for the cartel debacle with everyone at the CIA moving up a rank and Cruz eventually taking over the Lioness program.
A season or two from now, the bigwigs from the HUMINT office at Langley (Human Intelligence) bring the Lioness team a pitch presentation on a potential new target (much like Kyle's Lioness pitch deck in Season II, but suggesting a target, not an asset). This guy is another terrorist money man, gaining steam since the death of Asmar Ali Amrohi, Aaliyah's father, but far, far worse. The man is a true believer. He's a brutal fundamentalist and sadist. Now, he’s on the cusp of cementing himself as Amrohi’s successor by taking over his role in selling blackmarket oil to Russia and China. If allowed to consolidate power, this man represents an unprecedented threat to global security.
OK, sure… Sounds great… But what does this have to do with the Lioness program?
Well, the new money man has a new bride…
Next slide... Boom!
It's Aaliyah.
Cruz flips out, of course. Flat out refuses to have anything to do with this. She wants no part of it for entirely predictable reasons. She is, in point of fact, too wracked with guilt to even contemplate inflicting her presence on Aaliyah after the trauma inflicted last time out.
But... there's a twist!
Remember the bit how this new money guy is seeking to consolidate his power? Well, the CIA briefers inform the team that money man has coerced what’s left of Aaliyah’s family into making this arranged match. He has, in effect, “claimed” Aaliyah as a symbol that he’s the new sheriff in terrorist town. As part of the deal, Aaliyah is allowed to leave their compound and allowed limited travel with her own security detail. As you can imagine, though, even without knowing about Aaliyah’s sexual orientation, a woman of Aaliyah’s attitudes would not sit well with brutal, true-believing fundamentalist. The HUMINT team has evidence Aaliyah has been abused.
Between abuse, blackmail and a walking, talking psyche profile, the boys from Langley believe Aaliyah can be flipped. And now, Cruz has a reason to get involved that overrides her guilt. She owes it to Aaliyah to at least try to save her from this monster. Cruz agrees to the mission only after making Joe promise that once they kill the target, the higher-ups will let them her help Aaliyah.
Of course, Cruz can’t run the recruitment, so a new Lioness is selected. In a flip of the script, it’s now Cruz doing the interview. She is the manipulated no more, but now the manipulator – “Do you have any tattoos? No? Prove it.”
This new Lioness is embedded under some creative new cover. She makes contact with Aaliyah. Befriends her. She manoeuvres her Aaliyah to a secluded space to make the official approach.
But then, once alone in a quiet spot, Aaliyah starts questioning how seamlessly the new Lioness has ingratiated herself – currying Aaliyah’s favour, gaining her trust. It’s almost as if the Lioness knew the deepest secrets of Aaliyah’s heart, she says, things she’s only ever told one person in her whole life.
Aaaaaand… twist on a twist…
It’s a trap!
Yes, all of Cruz’s advice to the new Lioness on how to insinuate herself to Aaliyah stemmed from Cruz’s intimate knowledge of Aaliyah, as Cruz’s former lover and mark. But Aaliyah is not the same woman she was before her father’s death. While she still acts the joyful optimist, on the inside, Cruz’s betrayal has left Aaliyah broken, deeply suspicious and even paranoid.
In truth, Aaliyah clocked the new Lioness trying to pull her puppet strings from the start. She actually allowed the Lioness to manoeuvre her to a spot where she and her security would have the upper hand – and have a gun to the Lioness’s pretty little head. The QRF readies to storm the castle from a staging area nearby, but Cruz holds them back. Aaliyah’s shouting something out for all to hear. She knows the team will have this room wired. She calling for the grand puppetmaster to reveal themselves from behind the curtain.
In a callback to Cruz's SERE-on-steroids episode and the torture of Gutierrez, Asliyah's men tear the abaya off the Lioness's back and start drowning her in a nearby fountain or tub, bringing her up for air after before plunging her back under.
As Aaliyah rants and menaces, threatening the Lioness and reducing her to a blubbering mess, the nature of her demand becomes clearer…
The person Aaliyah expects to step forward… is Cruz!
This makes senae on multiple levels, from Aaliyah’s point of view Cruz is the great and spectacular villain of her life. It thus not a leap that Aaliyah would assume Cruz is behind all this. But this is also a logical conclusion given Aaliyah’s allusion, made while confronting the Lioness, to the fact that she believes only Cruz could have provided some of the insights the Lioness seemed to be leveraging in getting close to her.
Aaliyah’s patience is wearing this...
The Lioness is on the edge of suffocating...
The QRF once again readies to go out…
But they realize Cruz has slipped away!
Just then, as chaos is about to ensue, Cruz appears on screen.
She waltzes right into the kill room, hands in the air, giving herself up to save the new Lioness.
“Aaliyah: I’m right here.
Cut to Black.
I feel like this sets up not only a believable path for bringing Aaliyah back into the show, but for giving her and Cruz a plausible reason to interact on an ongoing basis for the whole season.
The more I think about it, the more I think that while this is still unlikely I kinda wanna see it happen.
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2024.11.29 22:50 Cool-Celebration-170 Hello, I'm in need of a job please

Hello everyone I'm looking for a job kindly. I'm in UAE and I'm looking for a job either house maid or any other. I'm Kenyan nationality and it will be my pleasure if I get one. Anyone who lives around Dubai kindly please consider my request if it's possible, I'll really appreciate
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2024.11.29 22:50 Own-Priority-53864 I don't listen to TAZ, but i'm warming up to Travis.

He's funny, no outrageous tweets for a while. He plays the character of lil' shit quite well. Wish him the best, jah bless
submitted by Own-Priority-53864 to TAZCirclejerk [link] [comments]


2024.11.29 22:50 ingading My newest and biggest piece, age 61, done by the amazing Rebecca Joy at La Luna Arts Collective in Orange, California

My newest and biggest piece, age 61, done by the amazing Rebecca Joy at La Luna Arts Collective in Orange, California Took 3 sessions, about 18 hours total
submitted by ingading to tattoo [link] [comments]


2024.11.29 22:50 SwiftieNewRomantics Gregg Wallace investigated by Channel 5 over new allegations

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2024.11.29 22:50 Effective_Scamp First Timer needs help!

Just did microneedling for the first time, and skin feels incredibly dry and tight. It is only been a few hours, but is it too early to put some vitamin E on it?
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2024.11.29 22:50 peach_juice_box Wishing To End Lease Early Due To A Layoff

I have a year-long lease which just renewed earlier in the month, which I was more than happy to let automatically renew, however, I found out yesterday that I am being laid off, and therefore will not have any significant income for the foreseeable future, and I need to end my lease ASAP to avoid missing rent payments and such in the future.
Internet searches so far have been extremely confusing and full of mixed messages, so I am here to ask if it is possible to end my lease early, and the process of that. I have sent a lengthy message to my landlord outlining my situation today, for the record.
Thanks so much!!
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2024.11.29 22:50 ForeverBri_96 Late but definitely thankful for life and this community 😊

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2024.11.29 22:50 External_Growth2174 Micro-scale Diagon Alley, thoughts?

Micro-scale Diagon Alley, thoughts? Saw this on facebook! I really like this micro-scale version as a good display piece at home! 💯
submitted by External_Growth2174 to lego [link] [comments]


2024.11.29 22:50 dk91245 ELI5 All observations are theory laden.

This is a quote by Karl Popper.
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2024.11.29 22:50 Elconejo_ Opinions on my shun build?

Any shun users out there ? I use a bruiser style comp in rta. Any suggestions on how to make him better. I went vio/will and would like him to be able to take a hit or two since I play turn two.
submitted by Elconejo_ to summonerswar [link] [comments]


2024.11.29 22:50 wuxiahiraeth Immersion course in S.Wales?

Dw i’n dysgu cymraeg Mynediad 1 gyda learn.welsh. I am looking for an immersion weekend type thing to help supplement my learning but I can’t seem to find anything based on south wales. Has anyone found anything like this?
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2024.11.29 22:50 adsraaf CAN YOU SURVIVE CALL OF DUTY BLACK OPS 6 PS5 CAMPAIGN?

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2024.11.29 22:50 Cpb1012 Looking for stars. 4 star for 12. 5 star for 16

Looking for stars. 4 star for 12. 5 star for 16 submitted by Cpb1012 to Monopoly_GO [link] [comments]


2024.11.29 22:50 SalaciousDumb Looking for games similar to LA Noire

Mainly looking for detective or other similar stories where you can investigate mysteries, find clues, interrogate subjects.
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2024.11.29 22:50 Flashy-Count6549 Best way to get co2 extinguisher dust off of a truck bed (hydrophobic)

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2024.11.29 22:50 NotEllis04 ASLOP IS BACK

Peak hath returned to us piggies
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2024.11.29 22:50 Alexkramner Inteligência Artificial!

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2024.11.29 22:50 Enzo_SuperCraftZ MINHOCA LOKA | toby fox - Sentou! Battle Tower [Challenge!] +HDDT (Sotarks, 11.05*) 92.41% 181/515x 3xMiss | 1160pp (1465pp if FC) | currently jerking off to this

MINHOCA LOKA | toby fox - Sentou! Battle Tower [Challenge!] +HDDT (Sotarks, 11.05*) 92.41% 181/515x 3xMiss | 1160pp (1465pp if FC) | currently jerking off to this submitted by Enzo_SuperCraftZ to osugame [link] [comments]


2024.11.29 22:50 insaneminecraft What makes bass pedals bass pedals

Hey! Im very new to building my own pedals and I have a question, what makes bass pedals actually keep bass frequencies? Im starting from diy kits and for some reason there are almost no bass kits so I started to wonder if it would be possible to get like a Rat copy and make it so that it doesn’t just delete bass frequencies. Is it like a specific component that takes care of this! Thanks!
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2024.11.29 22:50 LargeBreasts69 spooky’s side belly

spooky’s side belly submitted by LargeBreasts69 to catbellies [link] [comments]


2024.11.29 22:50 rjflesher Ready for a night out.

Ready for a night out. submitted by rjflesher to crossdressing [link] [comments]


2024.11.29 22:50 Branta-Canadensis What kind of baby snail is this?

What kind of baby snail is this? Sorry for the blurry pics, it is very small. I just added 2 rabbit snails and a mystery snail to the tank and this one showed up. I mainly need to make sure it's not an assassin
submitted by Branta-Canadensis to AquaticSnails [link] [comments]


2024.11.29 22:50 Skyler7381 Why buy hobby box over value or qualifying lap box? 2024

It seems the hobby box is quite a bit more per card or per pack, is there any reason to get the hobby box? It doesn't seem to have a guaranteed auto or anything either.
submitted by Skyler7381 to F1Cards [link] [comments]


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