The reliability of knowledge (turns to show bookshelves lol). I have set 3 of my power coins done! I think Cody's is the best looking combo as far as crests so far, I do wish I made the white grey but I ran out at some point.
2025.01.30 14:59 MTFPrint The reliability of knowledge (turns to show bookshelves lol). I have set 3 of my power coins done! I think Cody's is the best looking combo as far as crests so far, I do wish I made the white grey but I ran out at some point.
 | submitted by MTFPrint to digimon [link] [comments] |
2025.01.30 14:59 Silly-Living1761 Smithers
Hello everyone. Has anyone ever moved from Victoria to Smithers? My husband is from Northern BC and we are planning to move back to be closer to family. We are also priced out here. I'm a hybrid 4 days WFH with MCFD. I don't have a set location mentioned on my job profile. There's a MCFD office in Smithers. Just wondering what kinda paperwork is required for changing my designated office. Thanks
submitted by Silly-Living1761 to BCPublicServants [link] [comments]
2025.01.30 14:59 _randomguy-_- Immersive Dialga in the second pack!
 | Anyone else got this one? submitted by _randomguy-_- to PTCGP [link] [comments] |
2025.01.30 14:59 YordleWanderer Drag race to the finish line, But opponent is a sore loser.
https://reddit.com/link/1idotm7/video/0f8vljaea5ge1/player
I'm the red bull and I slowed down too much on T1 causing him to catch me about 0.5 until the recording started. I knew it was a drag race on the last lap and I would win it since I'm on the outside.
I won by 5 thousandths of a second and suddenly he punted me out of frustration.
submitted by YordleWanderer to Simracingstewards [link] [comments]
2025.01.30 14:59 DiligentPenguin16 Bugs & Beetles 🪲🪳
 | submitted by DiligentPenguin16 to nailstamping [link] [comments] |
2025.01.30 14:59 _darth_bacon_ Nine Calgary eateries make 2025 list of 100 Most Romantic Restaurants in Canada
 | The Calgary restaurants featured on the list include:
|
2025.01.30 14:59 trailer8k Warhammer 40,000_ Darktide - Grim Protocols _ Release Trailer
 | submitted by trailer8k to Trailerclub [link] [comments] |
2025.01.30 14:59 united-verdict-bot Unanimous "Not the A-hole" with 11 votes
submitted by united-verdict-bot to AmITheA_holeUnanimous [link] [comments]
2025.01.30 14:59 Responsible-Heat6842 Protein may be linked to exercise intolerance in ME/CFS (and those with Long Covid)
https://www.nih.gov/news-events/nih-research-matters/protein-may-be-linked-exercise-intolerance-me-cfs
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) afflicts more than 2 million people nationwide. People with ME/CFS live with debilitating symptoms including exhaustion, exercise intolerance, cognitive problems, and a worsening of symptoms after even mild exertion (known as post-exertional malaise).
The causes of ME/CFS remain poorly understood, although many people first develop symptoms after a viral infection. This gap in understanding limits both diagnosis and the development of treatments.
A team of NIH researchers led by Drs. Paul Hwang, Avindra Nath, and Brian Walitt have been studying a woman who took days to recover after physical exertion and several of her relatives at the NIH Clinical Center. Their findings were published on August 22, 2023, in the Proceedings of the National Academy of Sciences.
Tests done while the woman was exercising found a very slow recovery of cellular energy production after exertion. Muscle cells taken from the patient and examined in the lab showed reduced oxygen use. Oxygen is used by mitochondria, the cell compartment that makes energy molecules.
Further laboratory studies led the team to a protein called WASF3. This protein, which was boosted in response to cellular stress, disrupted the cells’ energy production. Blocking WASF3 allowed mitochondria to produce energy at normal levels. The team then showed that extra WASF3 in the cells interfered with formation of the structures that mitochondria use to produce energy.
To better understand the role of WASF3, the team engineered mice to produce excess WASF3. They found that, similar to people with post-exertional malaise, muscles in these mice were slow to recover after exercise. The mice also showed a 50% reduction in their ability to run on a treadmill, even though their muscle strength was comparable to mice without extra WASF3.
To see if WASF3 dysfunction might be involved in ME/CFS, the team compared muscle tissue samples taken from 14 people with ME/CFS to samples from 10 healthy volunteers. They found substantially higher levels of WASF3 in most of the people with ME/CFS.
This dysfunctional increase in WASF3 seemed to be linked to impairment of a cellular signaling pathway called the ER stress pathway. When the team treated human muscle cells with a compound known to increase ER stress, they saw a corresponding harmful increase in WASF3.
The researchers treated cells from the initial study participant with an experimental drug, called salubrinal, known to reduce ER stress. After this treatment, WASF3 levels decreased in the cells, more mitochondrial energy complexes formed, and energy production improved.
“We hope to embark on clinical studies to investigate whether this type of strategy can also work in patients to improve energy levels,” Hwang says.
Mitochondrial dysfunction has been found in some people with Long COVID and other conditions that include fatigue. More research is needed to understand whether targeting ER stress may also be a promising approach for these conditions.
—by Sharon Reynolds
submitted by Responsible-Heat6842 to covidlonghaulers [link] [comments]
2025.01.30 14:59 jimmyqex Selling my 2012 Volt: Wisconsin
2025.01.30 14:59 Way-of-the-bike Winter camping at 5°F
 | Another great trip. Got down to 5 degrees no issues turned truck off at 71% charge woke up it was still 71% then let it warm up while I packed up my gear zero issues. Only annoying thing is the dumb auto shutoff setting. I had a plan to run a heated blanket, turned off the auto shutoff setting plugged it in got into my tent all nice and cozy then it I hear the 30 second shutdown warning. Was not about to get out of my tent to deal with all that again and key fob command wasn’t working so abandoned the idea. Ford needs to thoroughly test the auto auto shutdown setting as once you turn it off other behavior like opening and closing doors seems to turn it back to on which is BS. Aside from that everything worked like a dream! submitted by Way-of-the-bike to F150Lightning [link] [comments] |
2025.01.30 14:59 SubmergetotheSweet A Little About Me!
 | submitted by SubmergetotheSweet to Inkitt [link] [comments] |
2025.01.30 14:59 AmbitiousEagle371 Where to buy Laptop Batteries
Just moved to bahrain and my laptop battery shit out on me. Unfortunately, Amazon will not ship this item to me so I need to find somewhere in town.
Any one know where i can find these so I don't have to spend the entire day searching?
I am in Manama.
TIA!
https://www.amazon.com/gp/product/B07WPTD6WJ/ref=ox_sc_saved_title_1?smid=A2QLWJ6UVPWJVA&psc=1
submitted by AmbitiousEagle371 to Bahrain [link] [comments]
2025.01.30 14:59 pixelary-game What is this?
This post contains content not supported on old Reddit. Click here to view the full post
submitted by pixelary-game to Pixelary [link] [comments]
2025.01.30 14:59 ImReallyNotFunny99 Widgets not working on iOS (and OSX)
Structured widgets are nearly always blurry on iOS. They work fine for the first 10 odd minutes and then never again. On Mac OS it’s better but could also be made more consistent. This has been the case across multiple iOS/ OSX versions, currently on the latest for each.
submitted by ImReallyNotFunny99 to structuredapp [link] [comments]
2025.01.30 14:59 bot_olini A Las Basuras De La 4t (p*nches Mentirosos) - Los Telegramas De Alazraki En Atypical
 | submitted by bot_olini to Mexico_News [link] [comments] |
2025.01.30 14:59 brawler_hasan I Recreated Every Brawler's Victory Animations in Real Life #1 - Brawl Stars
 | submitted by brawler_hasan to Brawl_Stars [link] [comments] |
2025.01.30 14:59 uphatbrew A Message to the US Senate: America is watching. Patel, Gabbard, and RFK are more than just unfit. They are a danger to our country, and to our people's safety. Use your vote to protect the people you represent. History will remember your choice…
 | submitted by uphatbrew to AntiTrumpAlliance [link] [comments] |
2025.01.30 14:59 Brokenman721 2 days in Lisbon
Hi all, I booked a last minute weekend getaway to Lisbon and can’t figure what I should do what to avoid this short time. I am staying in a hostel so any suggestions are welcome:)
submitted by Brokenman721 to LisbonPortugalTravel [link] [comments]
2025.01.30 14:59 Lalaland66666 First editing
 | submitted by Lalaland66666 to GachaClub [link] [comments] |
2025.01.30 14:59 Ashmit1018 Changes needed in JEE mains !!
- 25 QUESTIONS FOR ALL PCM SUBJECTS .
- Maths ka Conceptual Level 📈 , Maths ka calculation 📉
- Physics ka level 📈
- Take JEE for more days but students per day kam karo so that students ek dusre ke saath chipak ke na bethe taaki cheating kam ho
- One candidate should not be allowed for both JEE and NEET .
- NTA Should Conduct its own Free Mock Test Series With Mathongo Like analysis to prepare students for the CBT Mode
- Award Students who correctly report the incidents of cheating in their centres to curb cheating
submitted by Ashmit1018 to JEE [link] [comments]
2025.01.30 14:59 Kharov eBook College Accounting A Contemporary Approach ,6th Edition By John Price and Michael Farina M. David Haddock
Get this from our WEBSITE study resources in the sidebar or DM
submitted by Kharov to ScholarFriends [link] [comments]
2025.01.30 14:59 MrBenchly What is it like being a Brighton fan in the UK?
I am a relatively new Brighton fan, having started following them at the beginning of last season. I live in the States so I am surrounded by basketball, hockey, baseball, and American football fans, and I can count on one hand the number of times I've seen an adult in public wearing a Premier League team's apparel. And then it happened. Yesterday I was minding my own business when I noticed a man sitting across from me wearing an Everton shirt. And I suddenly felt like a dog with its hackles raised. All I could think about was the Veltman handball. Two weeks ago, I would have looked at him and thought, "oh look, another Premier League fan" but yesterday, all I had was this bitter, petty, shameful taste in my mouth. I left without saying a word.
For those of you surrounded by fans from other teams, how do you all act toward one another? Is it a friendly banter no matter their affiliation? An unfriendly banter? Do you not even notice each other? Are you more prone to speak up if it's a Palace or Chelsea fan? Or maybe depending on how Brighton has played against that team recently? I'm so curious!
submitted by MrBenchly to BrightonHoveAlbion [link] [comments]
2025.01.30 14:59 abdx56 اضافات دوم
 | السلام عليكم ممكن احد يشرحلي الYEAR ONE PASS حق دوم اترنل هل هو يحتوي على الاضافتين حقت دوم ولا لا submitted by abdx56 to saudi_gamers [link] [comments] |
2025.01.30 14:59 Komooui Don't do that, a la mode..
 | submitted by Komooui to Cookierun [link] [comments] |