2024.11.25 16:57 abjinternational Former Arsenal star Nicklas Bendtner caught up in HORROR knife attack while visiting New York - as Dane narrowly escapes serious injury
submitted by abjinternational to sportsnewstoday [link] [comments]
2024.11.25 16:57 Traditional-Care-87 [Hypothesis] Nutritional requirements for maintaining Cymbalta
I have a bizarre (silly?) hypothesis about SSRIs and SNRIs, and I'd like to hear your opinions on it.
I was using Cymbalta, but the effect disappeared after two months, and even increasing the dose no longer worked at all. (It had worked perfectly until then.)
This is called the poop out phenomenon, and someone on reddit told me that it is also related to receptor downregulation.
I accepted that, and while searching for other ways, I came across Piracetam.
When I took Piracetam, my brain fog and fatigue were significantly reduced. However, I heard that Piracetam sometimes requires choline, and that if you do not take that nutrient, the effect will disappear or a headache will occur.
Here, I felt that Cymbalta and Piracetam might have a similar mechanism.
In other words, just as Piracetam requires choline (some people need it), the hypothesis came to me that Cymbalta also requires some kind of nutrition to maintain its effect, and if you neglect to take it, it will no longer work.
Of course, the mechanism by which antidepressants stop working may be different for each person, and I do not claim that my hypothesis completely explains everything.
However, to simplify things, I thought that for example, in the case of Cymbalta, the effect may be maintained if you take something that is a source of nutrition for serotonin and norepinephrine.
The questions I would like to ask here are:
① Like the relationship between piracetam and choline, how likely is it that a deficiency of a specific nutrient is involved in the weakening of the effectiveness of Cymbalta (or SSRIs and SNRIs in general)?
② Based on my hypothesis, what nutrients do you think are important for making Cymbalta work again?
③ I thought about taking B vitamins and magnesium for serotonin, and copper and vitamin C for norepinephrine, but is this a hasty idea?
④ This may be off topic, but I have a strange reaction to vitamins. For example, when I take vitamin B (especially vitamin B12), I get auditory hallucinations and feel fatigued. Is there something wrong with methylation? In this case, should I selectively take only the B vitamins involved in serotonin synthesis?
⑤My main symptoms are brain fog, ADHD, chronic fatigue, dry throat, and dry eyes. Why do psychiatric drugs solve these? Cymbalta improved these "physical and physical" symptoms all at once in the first two months. I have almost no psychiatric symptoms at all.
This is a long story, so a partial answer is fine. My life was a mess because of chronic fatigue and brain fog, and I really felt like I got my life back during the period when Cymbalta was effective (not manic), so I hope Cymbalta will work again. Is there any good way? I'm ignorant, so please feel free to point out any points that may be useful, even if they are unrelated to my hypothesis.
submitted by Traditional-Care-87 to cymbalta [link] [comments]
2024.11.25 16:57 nb2sy [미국경제] 미국 재정적자 위기론의 붕괴 서막
* 이 글은 연속성 상에 작성되었으므로 본문이 이해가 잘 되지 않으시면 제 전 글을 참고해주시면 감사하겠습니다. https://preview.redd.it/g0bwrkejv23e1.png?width=679&format=png&auto=webp&s=f623b004cfb8611ccbd3da34241f01e5bffa74c7 11월 오늘까지 미국 단기채 신규발행량 $1948.65 누적$7834.43 이자지출$30.36 지급이자율 4.65% 이전 4.68%에서 0.03% 감소. 하였으며, 이는 9월 5.02% -> 10월 4.82% -> 11월 4.65% 로 연준의 금리 인하와 함께 당연하게도 같이 낮아지는 단기채 이자율과 함께 미국의 이자지출 총계도 낮아질 것을 암시합니다. 12월에도 25bp가 인하 예정되어 있으며, 저는 내년에는 QT종료와 함께 좀더 빠른 금리 인하를 예상하고 있습니다. submitted by nb2sy to Mogong [link] [comments] |
2024.11.25 16:57 Sweet_Leaa Do I look sexy in this?
submitted by Sweet_Leaa to SexyButNotNude [link] [comments] |
2024.11.25 16:57 Glum-System-7422 Does it matter if I see a movie opening weekend, vs. a few weeks later?
Seeing a movie in an almost empty theater is one of my favorite activities, but I've heard a few variations of "the studio makes more money the first couple weeks."
I don't care about making money for studios, per se, but I want to show support for smaller or independent films. If it's already a huge blockbuster then who cares, but if it's a limited release then I want to signal to studios that these are good movies to invest in.
Does it make a difference if I see it in the first week, vs the third or fourth? I'd love to avoid crowds (and all the idiots on their phones) but I don't want to lose independent movies in mainstream theaters.
submitted by Glum-System-7422 to NoStupidQuestions [link] [comments]
2024.11.25 16:57 GuavaOdd1975 Second time at Culver's. Same order, different location.
First time was in Charleston SC. This time, Sarasota Florida. Very consistent product. The cheese melted and stuck to the wrapper. submitted by GuavaOdd1975 to burgers [link] [comments] |
2024.11.25 16:57 polymute Uruguay election: opposition centre-left figure Yamandu Orsi wins presidential runoff
submitted by polymute to anime_titties [link] [comments] |
2024.11.25 16:57 Constant_Win9680 south asian domme new to this lol just turned 18 wanting to drain shameless subs and paypigs hehe
submitted by Constant_Win9680 to findommes [link] [comments] |
2024.11.25 16:57 Old-Board1553 New MBA M3 16GB owner here.
Hi guys. I just got my new Macbook Air M3 with 16gb ram today. Do you guys have like a list of games that you know run well on this, and how should I run them? But something you guys tried, not source from internet. :) Appriciate you all.
submitted by Old-Board1553 to macgaming [link] [comments]
2024.11.25 16:57 SamsSide 🏠 Crafted Survival [SMP] [Semi-Vanilla] 🌍 {Shopping District} 🎮 {Java & Bedrock Cross-Play 1.21.3} 🗺️ {Live World Map} 🛡️ {Grief-Free Land Claiming} 🎉 {Weekly Events & Community Projects} 🛠️ {Hermitcraft-Inspired} 🔗 IP: play.craftedsurvival.net | Bedrock Port: 19132
submitted by SamsSide to MinecraftSMPs [link] [comments]
2024.11.25 16:57 buggy22cat laibonich i love laibonich
im gonna repost all of my other laibonich art now too along with the new leaf one submitted by buggy22cat to CreaturesofSonaria [link] [comments] |
2024.11.25 16:57 designwdickens Where do you service your VW golf 🚘?
Hi guys, I’m currently looking for a specialized (not some random bush Merchanic) VW golf mechanics. Care to point me in the right direction?
submitted by designwdickens to Zambia [link] [comments]
2024.11.25 16:57 PrincessSaffronxx Your princess feet x
submitted by PrincessSaffronxx to Uk_feet [link] [comments] |
2024.11.25 16:57 Punch_Drunk_AA Can I refer the years of 2010 thru 2019 as the "twenty-teens?"
I know it isn't proper grammar, and I'll admit this is a blatant attempt to normalize the usage for this term.
But, is using "twenty-teens" to describe the years from 2010 thru 2019 a hill worth dying on? I'm willing to compromise and go 2013 to 2019, because starting at 2010 bugs some folks.
I am asking you dear Redditor, would it bug you if someone used "twenty-teens" in conversation?
submitted by Punch_Drunk_AA to NoStupidQuestions [link] [comments]
2024.11.25 16:57 Mektige Anyone here bought their 38WN95C from Amazon / Beach Camera?
This says fulfilled by Amazon, but it's from a company called Beach Camera, which has mixed reviews. The reviews for the monitor mention a LOT of issues, too. But since this is sold out everywhere else, this appears to be my only option. Any insight?
https://a.co/d/2qXOQck
submitted by Mektige to ultrawidemasterrace [link] [comments]
2024.11.25 16:57 diaeblo Need Help with College Projects? React JS, Spring Boot, Flutter & Firebase
Hi everyone,
Are you feeling stuck with your college projects or looking for expert guidance to get them done on time? I’m here to help!
I specialize in React JS, Spring Boot, Flutter, and Firebase, and I can assist you in completing your projects with:
2024.11.25 16:57 gregert55 Which is the best AI coding tool
Hi All,
I have been testing out the new Auto-gen coding tools: Bolt.new,Cursor,and Townie. I know that everyone has their own advantages and disadvantages but which one In your opinion is good enough to produce clean production ready code for Enterprise SAAS apps?
submitted by gregert55 to OnlyAICoding [link] [comments]
2024.11.25 16:57 jilinjames Karol G Will Have Her Own Bratz Doll: Here’s Where to Buy It
submitted by jilinjames to musicnews24 [link] [comments]
2024.11.25 16:57 CasSkeutjes Should i start Accutane? Please help me decide. Let me know your opinion after reading the story.
I'l try to keep this post relatively short. Cause i'm a person who is very good in making very long stories.
Im considering accutane and i got permission from my dermatologist to start. One blood test and i could swallow the first pill as soon as 1 week. See the image attached to see my skin status right now.
Right side of my face. as of november 24 2024
Im not sure to do Accutane cause:
- Im scared of side effects: Tinnitus (ringing in ears), blurry vision, hairloss, permanent dry lips, skin, eyelids, etc. Joint pain, Headaches and what not. Basically any side effect that will continue after the accutane cure. I dont want it and thats why im considering doing a very low dose accutane or even using it every other day so i try to avoid side effects as much as possible.
- I dont drink much water - I never reach 2 litres or 33oz in a day, i maybe drink 2 or 3 big glasses at most and that's it. Will Accutane destroy me if i keep up this habit of dr1nking so few? Or should i REALLY improve my hydrating before even starting? (Even if the liver test shows my liver is healthy)
- Fear of it coming back: This explains itself. Relapse rate (Rate of how often acne comes back) is about 35%. So i feel like Accutane is a 1 in 3 gamble that the acne will come back, or pretty much stay away forever. Im too scared to risk it (I think)
- I feel like i should try all the other options: As this title says, i feel like i should try all the creams, serums, diets out there before Accutane. Personally i think Accutane is a very extreme option for how bad my skin is (see image) And thats why im desperate to try all the products out there before Accutane as last resort.
What do you think when you read this? please let me know.
- Do you think i should stop whining, start already and take the risk? - Or do you agree for example that i should try a diet, different face wash, and live more healthy.
https://preview.redd.it/kbe6tchav23e1.jpg?width=776&format=pjpg&auto=webp&s=a2052d0838589e400baa8eaae3cb045205997f7b
submitted by CasSkeutjes to Accutane [link] [comments]
2024.11.25 16:57 validuser1 help me i will upvote your history if you get mine
up for up lets have a party
submitted by validuser1 to KarmaFarmer [link] [comments]
2024.11.25 16:57 steelscaled Let's talk about all the stuff Witches got in War of Immortals and Divine Mysteries
Hello to everyone. Witch as a class got a lot of attention from Paizo since remaster — familiar abilities, subclasses, feats. Some of this content is good and flavorful, some of it is… questionable (why do they keep insisting on Witch's Armament playstyle, it's not going to happen, Witch has a durability of a wet potato chip.) War of Immortals and Divine Mysteries had a lot of options for the class, so I wanted to share my thoughts about them.
Little heads-up: some of my analysis will be a bit pedantic and probably will have "you must be fun at parties" vibe. That's because I think that PF2e is a very literal game and intend to view it as such.
Let's get started.
Seneschal Class Archetype What a great archetype. Love the flavor, love the option to play as a witch that is no longer bound by the patron’s desires, as per description. However, mechanically, it has some erratable issues.
Manifest Will and Dedication Feat
Seneschal takes away your normal Hex cantrip and replaces it with Manifest Will. Hex cantrips are important for the remastered Witches as they enable constant use of your unique familiar ability, so naturally Manifest Will is one of the central parts of Seneschal playstyle.
Here's where problems are starting to show up:
You are concealed from creatures beyond the edge of the emanation but can’t use that concealment to Hide.Okay, sounds very simple: runes\symbols\energy\plants are swirling around you, making you concealed. But here's the thing: Manifest Will is one of the only ways to center an emanation on someone else (as per dedication feat at level 2).
When you cast or Sustain manifest will, as long as your charge is within 30 feet, you can choose to center the spell’s emanation on your charge instead of yourself.So, what about concealment? Everyone, except from creatures right in front of your charge, are "beyond the edge of the emanation". Should you be concealed from everyone? Is that the intent? I hardly believe it. Here's possible interpretations of what does it do when you're centering Manifest Will around someone else and you yourself isn't in emanation:
When you cast or Sustain manifest will, you can choose any tradition’s manifestation.It's awkward beyond belief. Say, you cast Divine Manifest Will, including a creature in the center square of an emanation in it (yourself or charge, doesn't really matter). Next turn, you sustain and want to change to a Primal or Arcane. Well, emanation already incudes a center square, so you\charge will get a penalty to speeds\weakness to spells. It works the other way around too. If you cast Arcane\Primal and then sustain and change to Divine\Occult, well, you probably didn't include a center square.
2024.11.25 16:57 sunsoulva [For hire] Hello! Wanna a artwork of your favorite pokémon? I OPEN COMISSIONS! I will draw an amazing and vibrant work of any pokemon for you, starting at 5dlr, just send a DM to talk
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2024.11.25 16:57 donovanwheels Some pickups from the show this weekend....
submitted by donovanwheels to comicbookcollecting [link] [comments] |
2024.11.25 16:57 Just_Advertising_382 Is this authentic?
submitted by Just_Advertising_382 to Burberry [link] [comments]
2024.11.25 16:57 UnifiedQuantumField Aliens miss the 90's
submitted by UnifiedQuantumField to FringeTheory [link] [comments] |